WebDec 2, 2024 · INTRODUCTION. In eukaryotes, DNA and histones form nucleosomes, which contribute to preserving genomic integrity (1,2).Histone proteins are decorated by post-translational modifications (), and this epigenetic information is important for nuclear events including transcription, DNA replication, and DNA repair ().In damaged chromatin, histone … WebYou need an antigen retrieval step in your IHC because formalin fixation of the tissue cross-links with antigens. You can apply heat (i.e. hot citrate buffer or EDTA) or use an …
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