Tigecycline pharmacokinetics
Tigecycline, a first-in-class glycylcycline antimicrobial agent, has an expanded spectrum of activity against gram-positive, gram-negative, aerobic, anaerobic, and atypical bacteria, including strains that are multidrug resistant. It is active against methicillin-resistant S. aureus, penicillin-resistant S. pneumoniae, … Visa mer Glycylcyclines are a novel class of antimicrobial agents, and tigecycline (figure 1) is the first of the glycylcyclines to reach the final stage of clinical development. Tigecycline inhibits translation of bacterial … Visa mer The pharmacokinetic properties of tigecycline have been studied in several animal species. Overall, the pharmacokinetics in animals is characterized by a low … Visa mer The pharmacokinetics of tigecycline, including metabolism and mass balance studies, have been evaluated in healthy subjects and in patients with complicated skin and skin-structure … Visa mer The interrelationship between the pharmacokinetics and pharmacodynamics of antimicrobial agents has become increasingly important. Data from in vitro and in vivo infection models, including dose fractionation … Visa mer Webbaltered by hemodialysis. The pharmacokinetics of tigecycline are also not affected by food, although tolerability is increased if the drug is administered following a meal. …
Tigecycline pharmacokinetics
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WebbThe pharmacokinetics (PK) of tigecycline in cerebrospinal fluid (CSF) was investigated by performing therapeutic drug monitoring (TDM). The pharmacodynamics (PD) of … Webb7 mars 2013 · Tigecycline clearance was reduced by approximately 20%, and area under the tigecycline concentration-time curve increased by approximately 30% in subjects …
Webb1 sep. 2005 · The level of tigecycline binding to protein is ∼78%. Tigecycline has a half-life of 36 h in humans, and on the basis of limited data, it does not appear that the either … WebbTigecycline exhibits linear pharmacokinetics and is safe and well tolerated in the dose ranges examined. Tigecycline, a novel, first-in-class glycylcycline (3, 17, 22, 26), has …
Webb1 feb. 2009 · Tigecycline pharmacokinetics were best described by a two-compartment model, with a mean half-life of 9.9 h. Protein binding was dose dependent (range, 92.9 to … Webb3 apr. 2024 · Hence, further data are required to elucidate the pharmacokinetics of tigecycline in liver-impaired critically ill patients. Therefore, we performed a population …
Webb25 maj 2012 · Tigecycline. Trade Names: ... Pharmacokinetics: administered i.v. only (acid labile). Serum half-life is long (42 hours). 60% biliary/fecal elimination. Notes: Many …
WebbEnterococci in the intestinal microflora were reduced, whereas the number of Enterobacteriaceae and Bacteroides remained relatively constant. Several strains of Bacteroides spp. resistant to tigecycline treatment … teaching grants in texasWebb13 juli 2024 · Tigecycline (TGC), the first antimicrobial of glycilcycline class, has shown an expanded-spectrum activity against gram-positive, gram-negative, aerobic, anaerobic … south lake tahoe webcams heavenlyWebb20 feb. 2024 · No dosage adjustment of tigecycline is considered necessary in patients with renal impairment or in patients undergoing hemodialysis, but data on the … teaching grants and scholarships ukWebb19 sep. 2024 · Population Pharmacokinetics of Tigecycline: A Systematic Review Abstract. Although tigecycline is widely used in clinical practice, its efficiency and optimal dosage … south lake tahoe weather nowWebb18 feb. 2024 · Tigecycline, the first broad-spectrum glycylcycline, is considered an appropriate agent for the treatment of complicated infections in critically ill patients or in … south lake tahoe wildfireWebb30 sep. 2024 · Tigecycline pharmacokinetics was investigated in two studies. The first study enrolled children aged 8-16 years (n=24) who received single doses of tigecycline … teaching grants for graduate schoolWebbTigecycline, a novel glycylcycline antibiotic, exhibits strong activity against gram-positive, gram-negative, aerobic, anaerobic, and atypical bacterial species, including many … south lake tahoe webcams heavenly village