Small vcp/p97-interacting protein expression

Author: qeie

August undefined, 2024

WebDihydrotestosterone Induces Proliferation, Migration, and Invasion of Human Glioblastoma Cell Lines WebApr 11, 2024 · The mRNA expression levels of HRD1, gp78, E3 ligase enzymes; p97/VCP, retrotranslocation protein; UFD1L and NPL4, cofactor proteins; OS9, ER lectin protein and UFD2A which functions as ubiquitin-chain elongation factor E3/E4 ubiquitin ligase were significantly up-regulated by dexamethasone induction in a dose-dependent manner (Fig. …

Q8NHG7 - UniProt

WebUsing substrate trapping in vitro and in vivo in the human Ewing sarcoma TC32 cell line, they identified valosin-containing protein (VCP/p97) as a new PTPN13 substrate. As VCP/p97 phosphorylation is necessary for PTPN13 midbody localization during cell division, a PTPN13 pro-oncogenic role in Ewing sarcoma, mediated through regulation of cell ... WebSmall p97/VCP-interacting protein (SVIP) was first discovered as one of the novel androgen-responsive genes as well as one of the many cofactors controlling p97/VCP. The aim of the study was to investigate localization and immunoexpression of p97/VCP and SVIP in … dhx media compilation youtube

SVIP Induces Localization of p97/VCP to the Plasma and …

WebMar 6, 2024 · Background: Endoplasmic reticulum-associated protein degradation (ERAD) eliminates misfolded proteins. Numerous illnesses, including cancer, cystic fibrosis, diabetes, and neurological diseases, are influenced by ERAD. ... Investigation of the effects of small VCP-interacting protein (SVIP) on the migration and invasion of breast cancer … Webproteins that interact speciﬁcally with VCP/p97 by using the yeast two-hybrid system, and discovered a novel VCP/p97-interacting protein named small VCP/p97-interacting protein (SVIP). Rat SVIP is a 76-amino acid protein that contains two putative coiled-coil regions, and potential myristoylation and palmitoylation sites at the N terminus. WebThe AAA (ATPase associated with various cellular activities) ATPase p97, also referred to as valosin-containing protein (VCP), mediates essential cellular processes, including ubiquitin-dependent protein degradation, and has been linked to several human proteinopathies. p97 interacts with multiple cofactors via its N-terminal (p97N) domain, a subset of which … cincinnati woman\\u0027s club lafayette

VCP protein expression summary - The Human Protein Atlas

The determination of the relationship between p97/VCP, small …

WebOct 11, 2013 · SVIP (small p97/VCP-interacting protein) was initially identified as one of many cofactors regulating the valosin containing protein (VCP), an AAA+ ATPase … Web开馆时间：周一至周日7:00-22:30 周五 7:00-12:00; 我的图书馆 cincinnati womans city clubWebDec 10, 2016 · This protein is a ubiquitin recognition factor protein which resides on the cytosolic side of ER membrane and forms a complex with the ubiquitin fusion degradation protein 1 (UFD1L, see below) and the valosin-containing protein (VCP, see below), also called p97 . A deficiency in any of the three members of the VCP/p97-UFD1L … cincinnati woman\u0027s club lafayette

"WebJul 12, 2024 · possesses therapeutic potential. For example, valosin-containing protein (VCP/p97) is a hub protein that interacts with more than 30 adaptor proteins involved in various cellular functions. However, the role of each p97 PPI during the relevant cellular event is underexplored. The development of small-molecule PPI modulators remains … " - Small vcp/p97-interacting protein expression

Small vcp/p97-interacting protein expression

Dexamethasone-stimulated glucocorticoid receptor signaling …

WebProtein names Recommended name Small VCP/p97-interacting protein Gene names Name SVIP Organism names Organism Homo sapiens (Human) Taxonomic identifier 9606 NCBI … WebOct 11, 2013 · Small VCP-interacting protein (SVIP) is a 9-kDa protein that is composed of 76 amino acids, and it plays a role in the endoplasmic reticulum-associated protein …

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WebGeldanamycin and Velcade, new anticancer drugs with novel mechanisms of action, are currently undergoing extensive clinical trials. Geldanamycin interrupts Hsp90 chaperone activity and causes down-re Web(A) Protein groups identified from single motor neurons (MNs) and interneurons (INs). (B) Venn diagram indicating overlap of identified protein groups. (C) Principle component …

WebSmall VCP/p97-interacting protein (SVIP) is involved in various cellular processes, including membrane fusion and ubiquitin-dependent protein degradation. SVIP functions as an … WebY. Amagasaki is an academic researcher. The author has contributed to research in topic(s): Precipitin & Antigen. The author has an hindex of 1, co-authored 1 publication(s) receiving 10 citation(s).

WebMar 1, 2024 · Small p97/VCP-interacting protein (SVIP) is an interacting cofactor that regulates the p97/valosin containing protein (VCP), an AAA + ATPase involved in the … WebTsujimoto Y, Tomita Y, Hoshida Y, et al. Elevated expression of valosin-containing protein (p97) is associated with poor prognosis of prostate cancer. Clin Cancer Res. 2004;10(9):3007–3012. 18. Cui Y, Niu M, Zhang X, Zhong Z, Wang J, Pang D. High expression of valosin-containing protein predicts poor prognosis in patients with breast …

WebUsing proteomic approaches, we identified VCP/p97 (valosin containing protein) as a novel neurofibromin interacting protein. The experiments combining cultured neurons and mouse genetic model suggest that VCP/p97 acts downstream of neurofibromin in controlling neuronal morphogenesis.

WebVCP stimulates the deubiquitinase activity of ATXN3 (ataxin 3) to stabilize BECN1 protein levels and also interacts with and promotes the assembly and kinase activity of the … dhx media creditsWebFeb 9, 2024 · Valosin containing protein (VCP) has emerged as a central protein in the regulation of the protein quality control (PQC) system. VCPmutations are causative of multisystem proteinopathies, which include neurodegenerative diseases (NDs), and share various signs of altered proteostasis, mainly associated with autophagy malfunctioning. dhx media groupWebWhile, VCP function was inhibited by small molecule VCP inhibitor Eeyarestatin I (EerI) [18] at a final concentration of 10 mM for 24 hrs and compared to DMSO control vehicle. The pcDNA3.1-VCP-myc and control plasmids were transfected as above for over expression experiments. Immunofluorescence Microscopy of Clinical Biopsies from NSCLC Patients- cincinnati woman\\u0027s clubWebThe encoded protein plays a role in protein degradation, intracellular membrane fusion, DNA repair and replication, regulation of the cell cycle, and activation of the NF-kappa B … dhx media mattel playground productionsWebValosin-containing protein (VCP) or transitional endoplasmic reticulum ATPase (TER ATPase) also known as p97 in mammals and CDC48 in S. cerevisiae, is an enzyme that in humans is encoded by the VCP gene. The … cincinnati wolfhounds rugby scheduleWebJan 18, 2024 · VCP/p97-Mediated Unfolding as a Principle in Protein Homeostasis and Signaling. The AAA+-type ATPase p97 governs an ever-expanding number of cellular … cincinnati woman\u0027s club cincinnati ohWebAug 31, 2011 · The small p97/VCP-interacting protein (SVIP) functions as an inhibitor of the endoplasmic reticulum (ER)-associated degradation (ERAD) pathway. Here we show that overexpression of SVIP in HeLa cells leads to localization of p97/VCP at the plasma membrane, intracellular foci and juxtanuclear vacuoles. cincinnati woman\\u0027s club cincinnati oh