Hif 1α激活剂
Web16 de jul. de 2024 · HIF-1α is regulated by a family of oxygen- and iron-dependent prolyl hydroxylases, HIF-1α accumulates and translocates into the nucleus, where it binds the constitutively expressed HIF-1β. The resultant heterodimer HIF-1 binds to hypoxic response elements of target gene regulatory sequences. 10 It has been reported that HIF-1α is a … Web12 de mar. de 2024 · Roles of HIF-1α in MIRI. Matsushima et al demonstrated that HIF-1α may protect cardiac fibroblasts from apoptosis and represent a potential therapeutic target for heart remodeling following hypoxic injury.Additionally, a number of studies have confirmed that HIF-1α prevents MIRI and has a cardioprotective effect (22,23).Protective …
Hif 1α激活剂
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Web20 de dez. de 2024 · 细胞信号通路详解之HIF1α通路. 动物细胞中，对氧气的感知和反应是一个非常重要的过程，在包括癌症、心血管疾病和中风在内的多种疾病的病理生理学中占 … Web高效、可逆的细胞通透性 hif-1α 抑制剂 (ec 50 = 1.2 nm) px 12. 不可逆的竞争性硫氧还蛋白-1 抑制剂；减弱 hif-1 的表达. 牡荆素（芹菜素 8-c-葡萄糖苷） 抗氧化、抗炎 hif-1α 抑制 …
Web21 de jul. de 2011 · Dominant-negative forms of hif-1αa and hif-1αb were generated using primers amplifying DNA corresponding to amino acids 1-330 of human HIF-1α. 32 Dominant-active forms of hif-1αa and hif-1αb were generated by successive rounds of site-directed mutagenesis. 20,33,34 In each round, one of the hydroxylation sites was … WebOltipraz抑制HIF-1α激活,这种作用具时间依赖性,浓度≥10μM时完全废除HIF-1α诱导,Oltipraz抑制HIF-1α,IC50为10μM。 注：本品仅可用于科研实验，严禁用于临床医疗及其他用途！ …
Web介绍. 10 µM，50-100次转染. siRNA产品通常包含3-5种目标特异的19-25 nt的siRNA，用于敲除基因表达. 如果需要确认某一种siRNA单独沉默HIF1a基因效果，可以申请单独购买某 … WebGN44028 是一种缺氧诱导因子 (HIF)-1的有效抑制剂，其IC50 值为 14 nM。. GN44028 能抑制低氧诱导的HIF-1α 的转录活性，但不抑制HIF-1α mRNA 的表达，HIF-1α 蛋白的累积 …
WebDASA-58是一种高度特异的小分子PKM2 激动剂, DASA-58抑制LPS诱导的 HIF -1α和IL - 1β, 以及一系列其它 Hif -1α依赖基因的表达。. 品牌：medchemexpress (MCE) 技术资 …
Web28 de abr. de 2014 · Moreover, no effect of HIFs (HIF-1α or HIF-2α) on CD80, CD86, PD-L2, PD-1, and CTLA-4 mRNA or protein levels was observed. To investigate whether PD-L1 is a direct HIF-1α target gene, we searched for potential HIF-1α–binding sites in the proximal promoter of mouse PD-L1 gene using fuzznuc (EMBOSS explorer) software. easy french toast recipe using brioche breadWeb1 de fev. de 2015 · Hypoxia and inflammation are intimately linked. It is known that nuclear factor κB (NF-κB) regulates the hypoxia-inducible factor (HIF) system, but little is known about how HIF regulates NF-κB. Here, we show that HIF-1α represses NF-κB-dependent gene expression. HIF-1α depletion results in increased NF-κB transcriptional activity both … curewell medical center berwynWeb7 de ago. de 2024 · 缺氧诱导因子1α（HIF-1α）是介导细胞参与缺氧反应的重要转录调控因子，可上调一系列与肝纤维化相关基因的表达促进肝纤维化。. 众所周知，肝星状细 … easy french twist hairstyleWeb9 de out. de 2007 · Abstract. Hypoxia-inducible factor 1 (HIF-1) is a basic helix-loop-helix-PAS domain transcription factor that is expressed in all metazoan organisms and is composed of HIF-1α and HIF-1β subunits. Under hypoxic conditions, HIF-1 regulates the transcription of hundreds of genes in a cell type–specific manner. The HIF-1α subunit is … easy french twist tutorialWeb18 de jun. de 2024 · hif-1 是一种异二聚体转录因子复合物，由两个亚基组成：应答 o2 的 hif-1α 亚基和结构性表达的 hif-1β 亚基。 完整的 HIF-1 复合物与控制各种过程（例如代 … easy french words in englishWebPolyclonal Antibody for studying HIF1A. Cited in 194 publications. Validated for Western Blotting. Highly specific and rigorously validated in-house, HIF-1α Antibody (CST #3716) … easy french words to sayWebHIF-1α is a transcriptional factor encoded by the HIF1A gene located within chromosome 14q21-24 and is formed by 15 exons; HIF-1α consists of 826 amino acids and it has a molecular weight of 120 kDa. 48 48 Loboda A, Jozkowicz A, Dulak J. HIF-1 and HIF-2 transcription factors–similar but not identical. easy french words list