Dichloromethane mutagenicity
WebEnzyme-mediated dichloromethane toxicity and mutagenicity of bacterial and mammalian dichloromethane-active glutathione S-transferases. The kinetic properties of bacterial … WebDichloromethane caused a reproducible positive response in bacterial tester strains TA98, TA100, TA1535, and G46 at all doses used with these strains, both with and …
Dichloromethane mutagenicity
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WebMutagenicity: DNA inhibition: Human, Fibroblast = 5000 ppm/1H (Continuous).; Morphological transformation: Rat, Embryo = 160 umol/L.; DNA damage: Oral, rat = 1275 mg/kg.; ... The neurotoxicity is thought to be due to a direct nonspecific CNS depressant action of dichloromethane and to indirect effects of carbon monoxide. … WebU.S EPA Web Server
WebIn vivo mutagenicity was analyzed by gpt mutation/Spi-assays in the livers of rats. In addition, gene and protein expression of CYP2E1 and GSTT1, the major enzymes … WebEnzyme-mediated dichloromethane toxicity and mutagenicity of bacterial and mammalian dichloromethane-active glutathione S-transferases Daniel Gisi, Thomas Leisinger & …
WebAgency for Toxic Substances and Disease Registry WebAug 15, 1983 · Four dihalomethanes; dichloromethane, bromochloromethane, dibromomethane and diiodomethane, have been studied with respect to their reactivities …
WebDichloromethane was originally selected for substance evaluation in order to clarify concerns about: - Carcinogenic - Suspected mutagenic - Suspected reprotoxic - …
WebDichloromethane (DCM) is a colorless liquid with a sweet, pleasant odor. The major use of DCM is as a solvent in the pharmaceutical and chemical industry for reactions, purification and isolation of intermediates or products. highway 67 motorsportsWeb1,2-Dichloropropane (1,2-DCP) and dichloromethane (DCM) are possible causative agents associated with the development of cholangiocarcinoma in employees working in printing plant in Osaka, Japan. However, few reports have demonstrated an association between these agents and cholangiocarcinoma in rod … small speed boat kitWebGerm cell mutagenicity No data available Carcinogenicity Evidence of a carcinogenic effect. IARC: 2A - Group 2A: Probably carcinogenic to humans (Dichloromethane) NTP: RAHC - Reasonably anticipated to be a human carcinogen (Dichloromethane) OSHA: OSHA specifically regulated carcinogen (Dichloromethane) Reproductive toxicity No … small speeches in englishWebMay 17, 2024 · Since the mutagenicity of DCM was significantly increased in TA100-GST compared with mock control (TA100-pCTC), GSTT1 is thought to be involved in the … highway 67 texasWebDichloromethane, Methylene dichloride CAS No. 75-09-2 RTECS No. PA8050000. DOT ID & Guide. 1593 160. Formula. CH₂Cl₂ ... highway 68 cliftonWebfor mutagenicity of a cosmetic substance to be annexed in the Regulation (EC) No 1223/2009 should include tests to provide information on the three genotoxic endpoints, namely 1) mutagenicity at the gene level, 2) chromosome breakage and/or rearrangements (clastogenicity), and 3) numerical chromosome aberrations (aneuploidy). This small speed boat brandsWebThe mutagenicity of dichloromethane was evaluated in Salmonella bacterial tester strains TA98, TA100, TA1535, TA1537, and TA1538 and Saccharomyces cerevisiae yeast … small speed boats for sale