WebNov 21, 2011 · The motif discovery portion of the ELM resource has added conservation, and structural attributes have been incorporated to aid users to discriminate biologically relevant motifs from ... WebSep 10, 2014 · Biologically relevant linear motifs often exhibit a statistical significance that lies in or near the twilight zone (i.e. where there is a non-negligible probability to observe a random motif) . This difficulty begs for a better understanding and characterization of motif statistical significance [2] , [18] , and calls for alternative approaches.

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WebSep 6, 2012 · This highlights a caveat in predicting expression from motifs; while we can identify biologically relevant motifs, this type of analysis only suggests a subset of … WebSep 9, 2024 · Crosslinking and immunoprecipitation (CLIP) is a method used to identify in vivo RNA–protein binding sites on a transcriptome-wide scale. With the increasing amounts of available data for RNA-binding proteins (RBPs), it is important to understand to what degree the enriched motifs specify the RNA-binding profiles of RBPs in cells. We … foch wax thionville

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WebAug 22, 2008 · Having chosen biologically relevant motif MHG p-value thresholds, we next compared the KMM motifs found by our motif finder for the TF-condition sets with the motifs published by MacIsaac et al. . For each TF-condition set, we allowed the motif finder to output up to five unique motifs. Only those that passed their sets' bin threshold were ... WebJul 1, 2024 · Studies demonstrating their existence in the human genome and role in gene regulation are now shining light on their biological relevance. Herein, we review the … WebJan 11, 2024 · We show that LncLOOM is capable of identifying specific, biologically relevant motifs which are conserved throughout vertebrates and beyond in lncRNAs … fochville apartments to rent